Comparative Analysis of Closely Related Draft Genomes (11/25/2013)


Mon, 11/25/2013 at 10:22 AM

Customer is a yeast geneticist. He says his team has generated draft genome sequences for several closely related species, and assembled them in scaffolds, and would ask AccuraScience to generate a Genbank entry of unannotated scaffolds to get an accession number for publication, generate an annotation of every gene, and compare species of the same genus and map similarities and differences, e.g., protein sequence identity, homologs, missing genes, duplicated genes and analysis degree of synteny/co-linearity.

Mon, 11/25/2013 at 9:29 PM

AccuraScience LB: We will be able to do all the tasks you listed. Would appreciate more information about the project, e.g., the size of the genome, what level of functional annotation for the genes is required – will you be needing gene names or you also would want GO annotations? For the cross-species comparison, besides the species that you have the draft genomes of, are there any more in the same genus that need to be included? This is important because the complexity (and computation time) would rise very sharply with the number of species included in the comparison.

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Note: LB stands for Lead Bioinformatician. An AccuraScience LB is a senior bioinformatics expert and leader of an AccuraScience data analysis team.

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